While most of the work on Alzheimer's has centered around the amyloid hypothesis (or here), another possible set of proteins involved in the disease seems to be yielding promising results:
http://www.sciencedaily.com/releases/2010/05/100525103935.htm
I'm always interested to hear about ideas that don't involve amyloid beta proteins, not because I don't believe they are important to Alzheimer's disease pathology, but I am not convinced that they are the only players in the story (or even the main character).
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